Rifampin is associated with orange-red discoloration of which bodily fluids?

• A. Blue-green discoloration of urine
• B. Orange-red discoloration of urine, sweat, and tears
• C. No discoloration
• D. Brown discoloration of tears

Answer: (B)

Rifampin has a distinctive pigment that colors body fluids, so it often causes a harmless orange-red tint in urine, sweat, and tears. This is a well-known side effect and reflects the drug’s excretion in these secretions, not a sign of toxicity. Patients should be told that the color change is temporary and not harmful, though it can stain contact lenses and fabrics. Because of this pigment, the statement that describes orange-red discoloration of urine, sweat, and tears is the best answer. Other color changes listed don’t match rifampin’s known effects, and no discoloration isn’t accurate.