What is a typical sign of rifampin-induced hepatotoxicity?

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Multiple Choice

What is a typical sign of rifampin-induced hepatotoxicity?

Explanation:
Rifampin-induced hepatotoxicity shows evidence of liver injury both clinically and on labs. The typical picture is jaundice accompanied by elevated transaminases (AST/ALT) and often increased bilirubin, which together explain fatigue and yellowing of the skin or eyes. This combination of symptoms and abnormal liver tests is the most characteristic sign of rifampin-related liver injury. Nausea alone, a rash, or weight loss without these liver-test abnormalities is not as specific for this toxicity.

Rifampin-induced hepatotoxicity shows evidence of liver injury both clinically and on labs. The typical picture is jaundice accompanied by elevated transaminases (AST/ALT) and often increased bilirubin, which together explain fatigue and yellowing of the skin or eyes. This combination of symptoms and abnormal liver tests is the most characteristic sign of rifampin-related liver injury. Nausea alone, a rash, or weight loss without these liver-test abnormalities is not as specific for this toxicity.

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