Which drug is commonly added to MDR-TB regimens and has a distinctive skin discoloration side effect?

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Multiple Choice

Which drug is commonly added to MDR-TB regimens and has a distinctive skin discoloration side effect?

This item tests recognizing a MDR-TB drug known for a distinctive cosmetic side effect. Clofazimine is added to MDR-TB regimens because of its activity against certain resistant strains. Its hallmark adverse effect is skin discoloration, giving a reddish-brown to black hue that can persist and be most noticeable on the face and exposed areas. This pigmentation is a characteristic feature that helps distinguish it from other second-line TB drugs.

In contrast, the other drugs don’t cause this kind of skin staining: isoniazid is mainly associated with neuropathy and hepatotoxicity; ethambutol with optic neuritis; and pyrazinamide with hyperuricemia and hepatotoxicity.

Which drug is commonly added to MDR-TB regimens and has a distinctive skin discoloration side effect?

Prepare for the Antitubercular Drugs Test with our extensive questions, flashcards, and explanations. Master your understanding before your exam.

Which drug is commonly added to MDR-TB regimens and has a distinctive skin discoloration side effect?

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