Which of the following adverse effects should be reported promptly by a patient on isoniazid?

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Multiple Choice

Which of the following adverse effects should be reported promptly by a patient on isoniazid?

Explanation:
Isoniazid can cause peripheral neuropathy from pyridoxine (vitamin B6) deficiency. The key sign to report promptly is numbness and tingling in the feet because recognizing this early allows immediate steps to prevent progression—typically adding or increasing pyridoxine supplementation and reviewing the INH dose or regimen if needed. This neurotoxicity is often dose-related and can be reversible if addressed early. Other effects like headache, rash, or nausea can occur but are not as urgent; rash may require evaluation for hypersensitivity, but numbness/tingling is the most important signal to act on quickly.

Isoniazid can cause peripheral neuropathy from pyridoxine (vitamin B6) deficiency. The key sign to report promptly is numbness and tingling in the feet because recognizing this early allows immediate steps to prevent progression—typically adding or increasing pyridoxine supplementation and reviewing the INH dose or regimen if needed. This neurotoxicity is often dose-related and can be reversible if addressed early. Other effects like headache, rash, or nausea can occur but are not as urgent; rash may require evaluation for hypersensitivity, but numbness/tingling is the most important signal to act on quickly.

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