Which RIPE drug is usually avoided in pregnancy due to fetal risk?

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Multiple Choice

Which RIPE drug is usually avoided in pregnancy due to fetal risk?

Explanation:
In pregnancy, choosing anti-TB drugs hinges on fetal safety. Streptomycin is an aminoglycoside that can cross the placenta and cause fetal ototoxicity (and potential nephrotoxicity). This risk of irreversible hearing loss in the fetus makes streptomycin usually avoided during pregnancy unless there are no better options for drug-resistant TB and the benefits clearly outweigh the risks. The other drugs listed are used in pregnancy with appropriate precautions: isoniazid is given with pyridoxine to prevent neuropathy, rifampin is generally considered safe, and ethambutol is used with monitoring for optic toxicity.

In pregnancy, choosing anti-TB drugs hinges on fetal safety. Streptomycin is an aminoglycoside that can cross the placenta and cause fetal ototoxicity (and potential nephrotoxicity). This risk of irreversible hearing loss in the fetus makes streptomycin usually avoided during pregnancy unless there are no better options for drug-resistant TB and the benefits clearly outweigh the risks.

The other drugs listed are used in pregnancy with appropriate precautions: isoniazid is given with pyridoxine to prevent neuropathy, rifampin is generally considered safe, and ethambutol is used with monitoring for optic toxicity.

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