Which TB medication is most likely to cause discoloration of body fluids (such as urine)?

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Multiple Choice

Which TB medication is most likely to cause discoloration of body fluids (such as urine)?

Explanation:
Discoloration of body fluids is a hallmark adverse effect of rifampin. The drug has a strong orange pigment that is excreted in urine, sweat, and tears, giving fluids and sometimes contact lenses an orange-red tint. The effect is harmless but noticeable, so patients should be warned. Among the drugs listed, this pigment-related fluid discoloration is most characteristic of rifampin. Other TB medications are known for different adverse effects—isoniazid mainly causes liver toxicity and neuropathy, pyrazinamide can raise uric acid and also affect the liver, and ethambutol can cause optic neuritis and color-vision changes.

Discoloration of body fluids is a hallmark adverse effect of rifampin. The drug has a strong orange pigment that is excreted in urine, sweat, and tears, giving fluids and sometimes contact lenses an orange-red tint. The effect is harmless but noticeable, so patients should be warned.

Among the drugs listed, this pigment-related fluid discoloration is most characteristic of rifampin. Other TB medications are known for different adverse effects—isoniazid mainly causes liver toxicity and neuropathy, pyrazinamide can raise uric acid and also affect the liver, and ethambutol can cause optic neuritis and color-vision changes.

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