Which two MDR-TB drugs require monitoring of the QT interval during therapy?

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Multiple Choice

Which two MDR-TB drugs require monitoring of the QT interval during therapy?

Explanation:
QT interval prolongation is a key safety concern with certain MDR-TB drugs, so monitoring the heart's electrical activity with ECGs during therapy helps detect dangerous changes early. Bedaquiline and delamanid are both known to prolong the QT interval, so baseline and periodic QTc assessments are recommended, along with checking electrolytes and avoiding other QT-prolonging drugs when possible. The other drugs listed do not carry the same primary risk of QT prolongation, and their safety monitoring focuses on different issues.

QT interval prolongation is a key safety concern with certain MDR-TB drugs, so monitoring the heart's electrical activity with ECGs during therapy helps detect dangerous changes early. Bedaquiline and delamanid are both known to prolong the QT interval, so baseline and periodic QTc assessments are recommended, along with checking electrolytes and avoiding other QT-prolonging drugs when possible. The other drugs listed do not carry the same primary risk of QT prolongation, and their safety monitoring focuses on different issues.

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