Why should alcohol be avoided with isoniazid therapy?

• A. It can cause serious hepatic toxicity
• B. It has no interaction with alcohol
• C. It does not affect liver enzymes
• D. It can improve digestion

Answer: (A)

The key idea is that alcohol and isoniazid both challenge the liver, and taking them together increases the risk of serious liver injury. Isoniazid can cause hepatotoxicity on its own, and alcohol also harms the liver and can raise liver enzyme levels. When combined, the likelihood and severity of hepatitis or other liver damage rise, so avoiding or limiting alcohol during isoniazid therapy is advised. Monitoring liver function tests helps catch any trouble early, and symptoms like fatigue, nausea, abdominal pain, dark urine, or yellowing of the skin or eyes should prompt medical evaluation. Alcohol does interact with isoniazid by increasing hepatotoxic risk, it can affect liver enzymes, and it does not improve digestion, so those statements aren’t correct.